Mahendra Singh Dhoni's embattled side - which has failed to claim a single victory in the five-match ODI series against Australia so far - will now aim to salvage some pride when they take on the hosts in the final match at the Sydney Cricket Ground on Saturday.
Meanwhile, Australia will aim to extend their winning streak at home to 19 matches as they look to claim a 5-0 whitewash against India.
If India go down 0-5 to Australia, then the visitors will drop to number three in the ODI rankings from their current number two spot.
Indian spinner Ravichandran Ashwin is likely to be recalled to the team at the expense of Rishi Dhawan in the inconsequential final match - while Axar Patel could also get a nod for the first time in the series.
Indian opener Ajinkya Rahane, who split the webbing on his right hand during the fourth ODI, is likely to be replaced by Manish Pandey.
The hosts may choose to rest Shaun Marsh and Scott Boland again at the Sydney Cricket Ground.
Australia had earlier clinched the ODI series with an unassailable 4-0 lead following their 25-run victory over India in the previous match at Canberra.