Tennis stalwarts Novak Djokovic and Roger Federer will aim to book their place in the semi-finals of the Wimbledon when they take on their respective opponents in the fifth round of the men's singles event on 12 July.
While Djokovic will take on 11th seeded Tomas Berdych, Federer will lock horns with Canada's Milos Raonic.
Djokovic Adrian defeated Mannarino 6-2, 7-6 (7/5), 6-4 under the Centre Court roof on Tuesday.
The World Number Four needed a medical timeout, while leading 4-3 in the third set, for treatment on his right shoulder, and there was obvious relief as he claimed victory after two hours and 14 minutes.
Berdych hasn't defeated Djokovic since 2013 but he did triumph over the Serb at Wimbledon in the semi-finals seven years ago when the Czech finished runner-up to Nadal.
On the other hand, Federer eased into the quarterfinals for the 15th time at Wimbledon, as he defeated Bulgarian Grigor Dimitrov 6-4, 6-2, 6-4.
Raonic is 3-9 all-time against Federer, and 1-1 at Wimbledon heading into Wednesday's semi-final.